The function of ELF5 (E74 like ETS transcription factor 5, ENSG00000135374) is as follows. Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation. . Isoform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters. .