The function of ENSG00000135437 (RDH5, retinol dehydrogenase 5) is as follows. Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner (PubMed:10588954, PubMed:11675386, PubMed:9115228, PubMed:9931293). Has no activity towards all-trans retinal (By similarity). Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE). Also recognizes steroids (androsterone, androstanediol) as its substrates (PubMed:29541409, PubMed:9931293). {ECO:0000250|UniProtKB:Q27979, ECO:0000269|PubMed:10588954, ECO:0000269|PubMed:11675386, ECO:0000269|PubMed:29541409, ECO:0000269|PubMed:9115228, ECO:0000269|PubMed:9931293}.