The function of Ensembl gene identifier ENSG00000135702 (CHST5, carbohydrate sulfotransferase 5) is as follows. Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O- linked sugars of mucin-type acceptors (PubMed:10491328, PubMed:12218059, PubMed:12626414, PubMed:30093410). Acts on the non- reducing terminal GlcNAc of short carbohydrate substrates (in vitro) (PubMed:12218059). Preferentially add sulfate onto core 2- based O- glycan structures, but does not act on extended core 1 structures (in vitro) (PubMed:30093410). Involved in sulfation of endothelial mucins such as GLYCAM1 (PubMed:10491328, PubMed:12855678). Has no activity toward keratan (PubMed:11278593). Not involved in generating HEV- expressed ligands for SELL (PubMed:12855678). {ECO:0000269|PubMed:10491328, ECO:0000269|PubMed:11278593, ECO:0000269|PubMed:12218059, ECO:0000269|PubMed:12626414, ECO:0000269|PubMed:12855678, ECO:0000269|PubMed:30093410}.