The function of Ensembl gene identifier ENSG00000137252 (HCRTR2, hypocretin receptor 2) is as follows. G protein-coupled receptor that binds neuropeptides orexin-A and orexin-B, two neuropeptides derived from a common precursor, prepro-orexin (PubMed:26950369, PubMed:33547286, PubMed:35614071, PubMed:9491897). Upon neuropeptide ligand binding, HCRTR2 can couple with both G(q)/11 and G(i)/o heterotrimeric G proteins thereby initiating distinct downstream signaling cascades (PubMed:35614071). Involved in regulating the sleep-wake cycle (By similarity). Contributes to central regulation of glucose homeostasis (By similarity). {ECO:0000250|UniProtKB:P58308, ECO:0000269|PubMed:26950369, ECO:0000269|PubMed:33547286, ECO:0000269|PubMed:35614071, ECO:0000269|PubMed:9491897}.