The function of PGBD1 (piggyBac transposable element derived 1, ENSG00000137338) is as follows. Transposase-derived from PiggyBac DNA transposons. Although it has been fully domesticated and lacks transposase activity, PGBD1 has acquired DNA-binding capability (PubMed:12955498, PubMed:35609796, PubMed:36205081). It preferentially binds in and around genes involved in neuronal development, leading to their transcriptional pausing. Notably, PGBD1 suppresses paraspeckle assembly in neuronal cells (PubMed:36205081). {ECO:0000269|PubMed:12955498, ECO:0000269|PubMed:35609796, ECO:0000269|PubMed:36205081}.