Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. {ECO:0000269|PubMed:17401110, ECO:0000269|PubMed:26494624}. Enterostatin has a biological activity as a satiety signal. . This is the function of CLPS (colipase, Ensembl gene identifier ENSG00000137392).