The function of DDX60 (DExD/H-box helicase 60, ENSG00000137628) is as follows. Positively regulates RIGI- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of RIGI to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV). Selectively reduces infectious titers of viruses that depend on type II IRES-mediated translation by modulating ribosome occupancy on type II IRES-containing viral mRNAs, without affecting type I IRES-mediated translation (PubMed:36256515). {ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:21791617, ECO:0000269|PubMed:36256515}.