E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (PubMed:12890487). Involved in the regulation of mitotic metaphase/anaphase transition (PubMed:24163370). . This is the function of HECW2 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2, ENSG00000138411).