The function of HERC3 (HECT and RLD domain containing E3 ubiquitin protein ligase 3, Ensembl gene identifier ENSG00000138641) is as follows. E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. .