Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. . [Medin]: Main constituent of aortic medial amyloid. . This is the function of MFGE8 (milk fat globule EGF and factor V/VIII domain containing, Ensembl gene identifier ENSG00000140545).