The function of TTYH2 (tweety family member 2, Ensembl gene identifier ENSG00000141540) is as follows. Calcium-independent, swelling-dependent volume-regulated anion channel (VRAC-swell) which plays a pivotal role in the process of regulatory volume decrease (RVD) in the brain through the efflux of anions like chloride and organic osmolytes like glutamate (By similarity). Probable large-conductance Ca(2+)-activated chloride channel (PubMed:15010458). {ECO:0000250|UniProtKB:Q3TH73, ECO:0000269|PubMed:15010458}.