The function of IL19 (interleukin 19, Ensembl gene identifier ENSG00000142224) is as follows. Cytokine that functions as an anti-inflammatory and proangiogenic factor (PubMed:34932373). Polarizes adaptive immunity to an anti-inflammatory phenotype through induction of T-helper 2 responses by both down-regulation of IFN-gamma and up-regulation of IL4 and IL13 (PubMed:16365913). Produced by osteocytes, stimulates granulopoiesis and neutrophil formation (By similarity). Exerts its biological effect through a receptor complex consisting of a heterodimer of IL20RA and IL20RB (PubMed:12351624). In turn, activates the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, and importantly, STAT3 (PubMed:11564763). {ECO:0000250|UniProtKB:Q8CJ70, ECO:0000269|PubMed:11564763, ECO:0000269|PubMed:12351624, ECO:0000269|PubMed:16365913, ECO:0000269|PubMed:34932373}.