Possesses an intrinsic kinase activity (PubMed:24807905, PubMed:34764205). Phosphorylates GSK3B at 'Ser-9', leading to the activation of Wnt/beta-catenin signaling (PubMed:34764205). Additionally, exhibits a 3'-5'-DNA exonuclease activity that removes single nucleotides from the 3' terminus of single-stranded DNA substrates and digests overhanging mismatched 3' termini from double- stranded DNA substrates, possibly participating in DNA nucleolytic processing (PubMed:16313181). In vitro, does not seem to have nucleoside diphosphate kinase activity (PubMed:16313181, PubMed:24807905). Functional component of the gamma-tubulin ring complex, implicated in the regulation of its microtubule-nucleating activity in centrosomes, in a kinase activity-dependent manner (PubMed:24807905). May maintain primary cilium assembly and ciliary microtubule stability (PubMed:39824631). Part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, required for motile cilia beating (PubMed:36191189). {ECO:0000269|PubMed:16313181, ECO:0000269|PubMed:24807905, ECO:0000269|PubMed:34764205, ECO:0000269|PubMed:36191189, ECO:0000269|PubMed:39824631}. This is the function of NME7 (NME/NM23 family member 7, ENSG00000143156).