E2-like enzyme which specifically catalyzes the second step in ufmylation (PubMed:15071506, PubMed:29868776, PubMed:30626644, PubMed:34588452, PubMed:35394863, PubMed:36121123, PubMed:38383789). Accepts the ubiquitin-like modifier UFM1 from the E1 enzyme UBA5 and forms an intermediate with UFM1 via a thioester linkage (PubMed:15071506, PubMed:29868776, PubMed:34588452, PubMed:38383789). Ufmylation is involved in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (PubMed:27351204, PubMed:32160526, PubMed:35394863, PubMed:37036982, PubMed:38383789). {ECO:0000269|PubMed:15071506, ECO:0000269|PubMed:27351204, ECO:0000269|PubMed:29868776, ECO:0000269|PubMed:30626644, ECO:0000269|PubMed:32160526, ECO:0000269|PubMed:34588452, ECO:0000269|PubMed:35394863, ECO:0000269|PubMed:36121123, ECO:0000269|PubMed:37036982, ECO:0000269|PubMed:38383789}. This is the function of Ensembl gene identifier ENSG00000143222 (UFC1, ubiquitin-fold modifier conjugating enzyme 1).