The function of Ensembl gene identifier ENSG00000143627 (PKLR, pyruvate kinase L/R) is as follows. Pyruvate kinase that catalyzes the conversion of phosphoenolpyruvate to pyruvate with the synthesis of ATP, and which plays a key role in glycolysis (PubMed:11960989). Also produces the side product 2-phospholactate which can inhibit fructose-2,6- bisphosphate production (PubMed:27294321). 2-phospholactate can be dephosphorylated by PGP which prevents the inhibition of fructose-2,6- bisphosphate production and allows glycolysis to occur (PubMed:27294321). {ECO:0000269|PubMed:11960989, ECO:0000269|PubMed:27294321}.