Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:11139478, PubMed:15016832, PubMed:39478185). Forms a heteromeric ion channel with TRPC4 or TRPC5 that has reduced calcium permeability compared to the homomeric TRPC4 or TRPC5 channel (PubMed:39478185). Also permeable to monovalent ions including sodium, lithium and cesium ions (PubMed:39478185). {ECO:0000269|PubMed:11139478, ECO:0000269|PubMed:15016832, ECO:0000269|PubMed:39478185}. [Isoform Short]: Forms a receptor-activated non-selective calcium permeant cation channel. Also activated by intracellular calcium store depletion. . This is the function of Ensembl gene identifier ENSG00000144935 (TRPC1, transient receptor potential cation channel subfamily C member 1).