The function of UCN2 (urocortin 2, Ensembl gene identifier ENSG00000145040) is as follows. Hormone that plays a central role in whole body adaptation to stress (PubMed:11329063). Released by the hypothalamus primarily in response to physical or psychological stress and acts by binding to CRH receptor CRHR2 (PubMed:20966082). UCN2-dependent signaling regulates cardiovascular function, promotes skeletal muscle hypertrophy and manage energy balance and acts as an anorexigenic agent (By similarity). In contrast to CRH and UCN, does not activate the hypothalamus-pituitary-adrenal axis to promote corticotropin hormone (ACTH) production (PubMed:11329063). {ECO:0000250|UniProtKB:Q99ML8, ECO:0000269|PubMed:11329063, ECO:0000269|PubMed:20966082}.