The function of CRHBP (corticotropin releasing hormone binding protein, Ensembl gene identifier ENSG00000145708) is as follows. Specifically binds and inactivates the corticotropin- releasing hormone (CRH) and urocortin-1 (UCN) hormones, thereby inhibiting the hypothalamus-pituitary-adrenal axis and preventing corticotropin hormone (ACTH) production (PubMed:18234674, PubMed:1846945, PubMed:3494446, PubMed:7477348, PubMed:7585095). May be required to prevent inappropriate pituitary-adrenal stimulation in pregnancy (PubMed:7585095). {ECO:0000269|PubMed:18234674, ECO:0000269|PubMed:1846945, ECO:0000269|PubMed:3494446, ECO:0000269|PubMed:7477348, ECO:0000269|PubMed:7585095}.