Constitutively active G protein-coupled receptor that maintains high cAMP levels and contributes to several processes including neuronal development, through activation of intracellular signaling pathways via G(s). May be activated by lipid-derived agonists such as oleic acid or sphingosine 1-phosphate, leading to activation of the G(s)/cAMP/PKA signaling pathway (PubMed:12220620, PubMed:39626010). . This is the function of GPR6 (G protein-coupled receptor 6, ENSG00000146360).