The function of SLC16A2 (solute carrier family 16 member 2, Ensembl gene identifier ENSG00000147100) is as follows. Specific thyroid hormone transmembrane transporter, that mediates both uptake and efflux of thyroid hormones across the cell membrane independently of pH or a Na(+) gradient. Major substrates are the iodothyronines T3 and T4 and to a lesser extent rT3 and 3,3- diiodothyronine (3,3'-T2) (PubMed:16887882, PubMed:18337592, PubMed:20628049, PubMed:23550058, PubMed:27805744, PubMed:31436139, PubMed:26426690, PubMed:38661522, PubMed:40140416, PubMed:40368961, PubMed:40680733). Acts as an important mediator of thyroid hormone transport, especially T3, through the blood-brain barrier (Probable) (PubMed:28526555). Mediates the efflux of 3,5-diiodo-L-tyrosine (DIT) and 3-iodo-L-tyrosine (MIT) (PubMed:38661522). {ECO:0000269|PubMed:16887882, ECO:0000269|PubMed:18337592, ECO:0000269|PubMed:20628049, ECO:0000269|PubMed:23550058, ECO:0000269|PubMed:26426690, ECO:0000269|PubMed:27805744, ECO:0000269|PubMed:28526555, ECO:0000269|PubMed:31436139, ECO:0000269|PubMed:38661522, ECO:0000269|PubMed:40140416, ECO:0000269|PubMed:40368961, ECO:0000269|PubMed:40680733, ECO:0000305|PubMed:18636565}.