The function of Ensembl gene identifier ENSG00000148488 (ST8SIA6, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6) is as follows. Alpha-2,8-sialyltransferase that prefers O-glycans to N- glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups. .