The function of ENSG00000150045 (KLRF1, killer cell lectin like receptor F1) is as follows. Functions as an activating receptor involved in immunosurveillance upon binding to various ligands displayed at the surface of myeloid cells. Upon interaction with CLEC2B ligand, stimulates NK-cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells. Actviation of the common cytotoxicity pathway involves SRC and SYK kinases (PubMed:21149606). {ECO:0000269|PubMed:17057721, ECO:0000269|PubMed:21149606}.