The function of Ensembl gene identifier ENSG00000151376 (ME3, malic enzyme 3) is as follows. Catalyzes the oxidative decarboxylation of (S)-malate to pyruvate using NADP(+), and is able to reverse the reaction but only with significantly lower efficiency (PubMed:7818469). Can also catalyze the decarboxylation of oxaloacetate into pyruvate (By similarity). .