Metalloprotease that may play a role in the degradation of COMP. Also cleaves alpha-2 macroglobulin and aggregan. Has anti- tumorigenic properties. {ECO:0000269|PubMed:16611630, ECO:0000269|PubMed:17895370, ECO:0000269|PubMed:18485748}. This is the function of ADAMTS12 (ADAM metallopeptidase with thrombospondin type 1 motif 12, ENSG00000151388).