Plays a role in innate immunity (PubMed:35938871). Mechanistically, promotes alphaviruses RNA degradation by interacting with the viral polymerase nsP4 and the mRNA-capping enzyme nsP1 and thereby interfering with the interaction between viral RNA and nsP1 (PubMed:35938871). Essential for inflammation- and tissue injury- induced mechanical pain hypersensitivity (By similarity). . This is the function of Ensembl gene identifier ENSG00000151715 (TMEM45B, transmembrane protein 45B).