The function of TRIM36 (tripartite motif containing 36, Ensembl gene identifier ENSG00000152503) is as follows. E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins including CTNNB1, FOXA2 and AKT1 (PubMed:35768649, PubMed:37875418, PubMed:41323265). Involved in chromosome segregation and cell cycle regulation (PubMed:28087737). May play a role in the acrosome reaction and fertilization. Inhibits lung fibroblast proliferation, migration, and differentiation. Mechanistically, mediates 'Lys-48'-linked polyubiquitination of phospho-AKT1, leading to its proteasomal degradation and consequent inhibition of AKT signaling (PubMed:41323265). Promotes apoptosis via inhibition of the Wnt/beta- catenin signaling pathway (PubMed:35768649). Regulates ferroptosis by ubiquitinating and degrading FOXA2 (PubMed:37875418). {ECO:0000250|UniProtKB:Q80WG7, ECO:0000269|PubMed:28087737, ECO:0000269|PubMed:35768649, ECO:0000269|PubMed:37875418, ECO:0000269|PubMed:41323265}.