The function of Ensembl gene identifier ENSG00000153086 (ACMSD, aminocarboxymuconate semialdehyde decarboxylase) is as follows. Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS) (PubMed:12140278). ACMS can be converted non-enzymatically to quinolinate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite (PubMed:12140278). ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway (PubMed:12140278, PubMed:19843166). .