The function of SLC25A27 (solute carrier family 25 member 27, Ensembl gene identifier ENSG00000153291) is as follows. Facilitates proton transport across the inner mitochondrial membrane and may dissipate excessive proton gradient associated with oxidative and metabolic stress at neuronal synapses. Regulates glutamate-induced proton conductance in astrocytes, shifting the energy metabolism toward aerobic glycolysis and lactate transfer to neurons for ATP synthesis. Can transport chloride ions with lower efficiency. The transport mechanism remains to be elucidated. {ECO:0000250|UniProtKB:Q9D6D0, ECO:0000269|PubMed:10025957, ECO:0000269|PubMed:22524567, ECO:0000269|PubMed:26182433}.