The function of ENSG00000153292 (ADGRF1, adhesion G protein-coupled receptor F1) is as follows. Adhesion G protein-coupled receptor (aGPCR) for N- docosahexaenoylethanolamine (synaptamide), an omega-3 fatty acid lipid highly enriched in the brain (PubMed:27759003, PubMed:32144388). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:35418679, PubMed:36127364, PubMed:37120430). ADGRF1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed:35418679). Also able to couple to G(q), G(i) and G(12)/G(13) G proteins; additional evidence is however required to confirm this result in vivo (PubMed:36127364, PubMed:37120430). Involved in the development of neurons and cognitive function (By similarity). In liver, involved in fat accumulation (By similarity). {ECO:0000250|UniProtKB:Q8VEC3, ECO:0000269|PubMed:27759003, ECO:0000269|PubMed:32144388, ECO:0000269|PubMed:35418679, ECO:0000269|PubMed:36127364, ECO:0000269|PubMed:37120430}.