The function of ADAMTS1 (ADAM metallopeptidase with thrombospondin type 1 motif 1, ENSG00000154734) is as follows. Metalloprotease which cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Also cleaves COMP (PubMed:39672391). Has angiogenic inhibitor activity (PubMed:10438512). May play a critical role in follicular rupture (By similarity). {ECO:0000250|UniProtKB:P97857, ECO:0000269|PubMed:10438512, ECO:0000269|PubMed:39672391}.