The function of GHRL (ghrelin and obestatin prepropeptide, ENSG00000157017) is as follows. Precursor of the appetite-regulating peptide ghrelin, including ghrelin-27 and ghrelin-28. {ECO:0000269|PubMed:11306336, ECO:0000269|PubMed:35027551}. [Ghrelin-27]: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) (PubMed:10604470, PubMed:35027551). Induces the release of growth hormone from the pituitary (PubMed:10604470). Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. . [Ghrelin-28]: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) (PubMed:10604470, PubMed:35027551). Octanoylated ghrelin-28 is the most commonly found ghrelin and octanoylation is essential for the activation of the growth hormone secretagogue receptor type 1 (GHSR) (PubMed:11306336, PubMed:35027551). Induces the release of growth hormone from the pituitary (PubMed:10604470). Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. {ECO:0000269|PubMed:10604470, ECO:0000269|PubMed:11306336, ECO:0000269|PubMed:35027551}. [Obestatin]: May be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity). .