The function of Ensembl gene identifier ENSG00000158315 (RHBDL2, rhomboid like 2) is as follows. Regulator of proteosome activity independent of enzymatic activity (PubMed:26109405). Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors (PubMed:11672525, PubMed:15047175). Known substrate: EFNB3 (PubMed:15047175). {ECO:0000269|PubMed:11672525, ECO:0000269|PubMed:15047175, ECO:0000269|PubMed:26109405}.