The function of PKD1L1 (polycystin 1 like 1, transient receptor potential channel interacting, ENSG00000158683) is as follows. Component of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, without affecting cytoplasmic calcium concentration, and regulates sonic hedgehog/SHH signaling and GLI2 transcription (PubMed:24336289). The PKD1L1:PKD2L1 channel complex is mechanosensitive only at high pressures and is highly temperature sensitive (PubMed:24336289). Also involved in left/right axis specification downstream of nodal flow by forming a complex with PKD2 in cilia to facilitate flow detection in left/right patterning (By similarity). May function as a G protein-coupled receptor (PubMed:15203210). {ECO:0000250|UniProtKB:Q8R526, ECO:0000269|PubMed:15203210, ECO:0000269|PubMed:24336289}.