Orphan adhesion G protein-coupled receptor (aGPCR) (PubMed:37673336). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:37673336). ADGRG5 is specifically coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed:37673336). . This is the function of Ensembl gene identifier ENSG00000159618 (ADGRG5, adhesion G protein-coupled receptor G5).