The function of Ensembl gene identifier ENSG00000160145 (KALRN, kalirin RhoGEF kinase) is as follows. Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. .