Guanine nucleotide exchange factor for the Rho family of Ras- related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). . This is the function of VAV2 (vav guanine nucleotide exchange factor 2, Ensembl gene identifier ENSG00000160293).