The function of Ensembl gene identifier ENSG00000160446 (ZDHHC12, zDHHC palmitoyltransferase 12) is as follows. Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:36586411). Has a palmitoyltransferase activity toward gephyrin/GPHN, regulating its clustering at synapses and its function in gamma-aminobutyric acid receptor clustering (By similarity). Thereby, indirectly regulates GABAergic synaptic transmission (By similarity). Negatively regulates NLRP3-driven inflammation. Catalyzes NLRP3 palmitoylation, leading to its degradation via the chaperone-mediated autophagy (CMA) process (PubMed:36586411, PubMed:39225180). {ECO:0000250|UniProtKB:Q8VC90, ECO:0000269|PubMed:36586411, ECO:0000269|PubMed:39225180}.