The function of NPHS1 (NPHS1 adhesion molecule, nephrin, ENSG00000161270) is as follows. Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity). .