The function of Ensembl gene identifier ENSG00000162040 (HS3ST6, heparan sulfate-glucosamine 3-sulfotransferase 6) is as follows. Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to heparan sulfate. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate. . (Microbial infection) Acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. .