The function of ZG16B (zymogen granule protein 16B, Ensembl gene identifier ENSG00000162078) is as follows. Functions as a lectin that binds to selective commensal dental plaque bacteria, such as Streptococcus vestibularis. Contributes to maintain homeostasis in the oral microbiome by capturing commensal microbes and regulating their growth using a mucin-assisted clearance mechanism (PubMed:37216558). Plays an important role in pancreatic tumor progression and metastasis (PubMed:19302292, PubMed:36232715). Promotes pancreatic cancer cells migration and invasion through the TLR4/MyD88/NF-kappaB signaling pathway, without the involvement of the TLR4/TRIF pathway (PubMed:36232715). {ECO:0000269|PubMed:19302292, ECO:0000269|PubMed:36232715, ECO:0000269|PubMed:37216558}.