The function of ZSWIM2 (zinc finger SWIM-type containing 2, ENSG00000163012) is as follows. E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes. .