The function of NEURL3 (neuralized E3 ubiquitin protein ligase 3, Ensembl gene identifier ENSG00000163121) is as follows. E3 ubiquitin-protein ligase that plays a role in various biological processes such as lung development or innate immunity (PubMed:30111563). Seems to utilize UBE2E1. Promotes innate antiviral response by catalyzing 'Lys-63'-linked ubiquitination of IRF7 (PubMed:35792897). Also inhibits hepatitis C virus assembly by directly binding to viral E1 envelope glycoprotein to disrupt its interaction with E2 (PubMed:30111563). Plays an essential role in TLR4-mediated activation of MAPK pathways by promoting 'Lys-48'-linked polyubiquitination of the phosphatase DUSP1/MKP1 (PubMed:38667302). {ECO:0000269|PubMed:30111563, ECO:0000269|PubMed:35792897, ECO:0000269|PubMed:38667302}.