The function of Ensembl gene identifier ENSG00000163357 (DCST1, DC-STAMP domain containing 1) is as follows. E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteasomal degradation thereby negatively regulating type-I-interferon signaling. Essential sperm cell-surface protein required for sperm-egg fusion and fertilization (By similarity). {ECO:0000250|UniProtKB:Q059Y8, ECO:0000269|PubMed:27782195}.