The function of NAXE (NAD(P)HX epimerase, Ensembl gene identifier ENSG00000163382) is as follows. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) (PubMed:27616477). This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity). Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis (PubMed:23719382). {ECO:0000255|HAMAP-Rule:MF_03159, ECO:0000269|PubMed:23719382, ECO:0000269|PubMed:27616477}.