The function of CXCR1 (C-X-C motif chemokine receptor 1, ENSG00000163464) is as follows. Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor (PubMed:1840701). Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G- protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:8662698). {ECO:0000269|PubMed:1840701, ECO:0000269|PubMed:8662698}.