Plays a critical role in cortical radial and GnRH neurons migration during brain development. Regulates cortical radial migration by negatively controlling the activity of histone deacetylase 6 (HDAC6) and promotes centrosome maturation. CAMDI is required for dilation formation of cortical neurons during radial migration. Plays a critical role in learning and memory performance through regulation of AMPA- selective glutamate receptors (AMPARs) cell surface expression in competition with KIBRA. . This is the function of CCDC141 (coiled-coil domain containing 141, Ensembl gene identifier ENSG00000163492).