May catalyze calcium-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane. . [Isoform 1]: Has no phospholipid scramblase activity, due to the lack of a N-terminal proline-rich domain. . This is the function of ENSG00000163746 (PLSCR2, phospholipid scramblase 2).