The function of ENSG00000163958 (ZDHHC19, zDHHC palmitoyltransferase 19) is as follows. Palmitoyltransferase that mediates palmitoylation oproteins, such as RRAS and SQSTM1 (PubMed:20074548, PubMed:37802024). Catalyzes palmitoylation of RRAS, leading to increased cell viability (PubMed:20074548). Acts as a positive regulator of autophagy by mediating palmitoylation of SQSTM1, promoting affinity between SQSTM1 and ATG8 proteins and recruitment of ubiquitinated cargo proteins to autophagosomes (PubMed:37802024). Palmitoyltransferase activity may be crucial for spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q810M5, ECO:0000269|PubMed:20074548, ECO:0000269|PubMed:37802024}. (Microbial infection) Promotes Chikungunya virus (CHIKV) replication by mediating viral nsp1 palmitoylation. .