The function of ENSG00000164080 (RAD54L2, RAD54 like 2) is as follows. Helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner (By similarity). May stimulate the release of RNA polymerase II, that has paused near the transcription start sites of AR-targeted genes and unwind R-loops formed at these sites; R-loops result from the hybridization of the short RNA strand nascently synthesized by the paused RNA polymerase II molecule and the DNA template (PubMed:39028815). May also stimulate double-strand break formation by TOP2B, which appears important for transcriptional output (PubMed:39028815). Not able to remodel mononucleosomes in vitro (By similarity). .