Catalyzes the formation of the signaling molecule cAMP in response to G protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels (By similarity). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity). . This is the function of ADCY1 (adenylate cyclase 1, Ensembl gene identifier ENSG00000164742).